About the Study

Who runs this study?

The study is run by the Sjögren's Syndrome Clinic.
- Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland.
The Principal Investigator of this study is Blake Warner, DDS, Chief, Sjögren's Syndrome Clinic.

Our goals are:

To evaluate people thought to have Sjögren's syndrome or a disease similar to it to better understand how the disease begins and how it affects patients.
To follow patients during the course of the disease to understand how the disease changes over time and the effects of standard treatments.
Perhaps, most important, to do research studies to better understand what causes Sjögren's syndrome so that we can develop better ways to treat patients.

Each participant is in the study for approximately up to 5 years.
There are three core evaluations approximately every two years; and each evaluation is over a two or three day period.
Core evaluations include questionnaires, oral and head and neck examinations, saliva collection, physical examination, blood and urine tests, a dry eye examination, and salivary gland scintigraphy.
There may be additional visits in between the core evaluations if the participant's disease changes or if participant agrees to participate in some of the research studies in this protocol. Additional testing and procedures are optional, such as an ultrasound guided core needle biopsy of the parotid gland.
Some of the collected saliva, blood, and biopsy tissue (if obtained) may be used for research.

Email us at eileen.pelayo@nih.gov (or click on Contact). We will respond within 2 business days.

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